Tumors: discovered mechanism that blocks their growth


FRMP protein and its genetic inactivation in cancer cells may promote the reduction of cancer growth . A method to increase the survival of cancer patients. To say it is the subject of scientists from the Federal Polytechnic of Lausanne (EPFL) and the University Hospital of Lausanne.


The team used a mouse model to evaluate the effectiveness of an FMRP gene inactivation treatment. Scholars examined the potential of the protein FMRP to regulate the stability of neuronal RNAs . Scientists have discovered that immune evasion can lead to a protein abnormality in solid tumors. This can thwart the immune attack in cancer cells.

In the mice, the researchers inactivated the expression of the gene during the experiment. In animals, there was a reduction in tumor growth and an increased propensity for the effect of the immune system. Mice with the treatment had the highest survival. FMRP creates a barrier that allows cancer cells to avoid the immune response .


The widespread expression of FMRP in solid tumors together with the induction of its cancer regulatory network constitute a previously unknown mechanism by which tumors can escape the action of the immune system. Many human cancers develop the ability to evade the immune system, making them resistant to immunotherapeutic treatments. Current approaches to counteracting immune resistance are not always effective, and only in some patients lead to the desired results.


  • Discovered a mechanism that could counteract the growth of tumors (


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