Osteoporosis: prevention thanks to a new pharmacological compound

Osteoporosis: prevention thanks to a new pharmacological compound.


A discovery that offers a valid option to the hormonal treatments existing so far. A recent study in mice proves that it is possible to prevent and treat osteoporosis in patients. The solution appears to be a new drug compound to stimulate the body to form bones as bone mass increases. The new compound is based on the parathyroid hormone signaling pathway


Osteoporosis is a disease that gradually weakens bones, putting them at greater risk of breaking easily. Treatment involves strengthening the affected bones, stimulating the body to generate bone tissue, or maintaining bone density. A recent study investigated parathyroid hormone signaling involving two enzymes that inhibit bone growth and remodulation. The purpose of the drug is to inhibit enzymes called SIK2 and SIK3, to increase bone mass. The researchers delivered an oral form of the drug, SK-124. 

The results of the study demonstrated an increase in blood calcium and vitamin D, along with increased bone development in mice with the drug. Small molecules like SK-124 could represent next-generation oral bone-building treatments for osteoporosis. This new compound is currently being optimized and developed into a treatment for patients. 

  • New Oral Compound Could Prevent And Treat Osteoporosis (


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