Obesity gene: the revelation of the researchers

Obesity gene: the revelation of the researchers.


When food is absolutely delicious, it is also very harmful, such as high-calorie food. Major damage to human health. Scholars at Osaka Metropolitan University recently discovered that CREB-Regulated Transcription Coactivator 1 (CRTC1) is associated with obesity. When CRTC1 is knocked out in mice, they become obese. In practice, the functioning of CRTC1 suppresses obesity. CRTC1 is an expression of all neurons in the brain, those with the function of suppressing obesity.


CREB-regulated coactivator of transcription 1 (CRTC1) is a protein encoded by the CRTC1 gene in humans. It is present in the fetal brain and liver, adult heart, skeletal muscles, salivary glands, and adult central nervous system. The research team’s studies sought to understand how CRTC1 suppresses the mechanism of obesity. The study focused on neurons expressing the melanocortin-4 receptor (MC4R). In essence, the obesity gene RTC1 mediates the obesity-suppressing effects of the melanocortin-4 receptor ( MC4R .

Mutations of the MC4R gene are known to produce obesity, so the scientists stated that CRTC1 expression in MC4R-expressing neurons reduces obesity. The loss of CRTC1 in those neurons has had a major impact on obesity and diabetes . The experts therefore developed a line of mice that express CRTC1 normally apart from MC4R-expressing neurons where it is blocked. CRTC1-deficient mice that ate too much were more obese than control rodents. Finally, they acquired diabetes when they were fed a high-fat diet.


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